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From166US$ /night
Check-in
13Jan2026Select date
Check-out
14Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

1120 S Grange Avenue, Sioux Falls, South Dakota, United States, 57105
-
Near the Denny Sanford Premier Center
Great
8.7
9.3
/10
4.5
/5

The 3-star smoke-free Home2 Suites By Hilton Sioux Falls Sanford Medical Center hotel is located within 5 minutes' walk of the Sioux Empire Medical Museum and features 24-hour reception and wake-up service for guests' convenience. Located just 1.9 km from Michelangelo's David replica, this Sioux Falls hotel features luggage storage.

Location

The hotel is situated in the centre of Sioux Falls, near restaurants and theatres. The Lucky Lady Casino in Sioux Falls is a short way from the Home2 Suites.

The accommodation also takes you to USS South Dakota Battleship Memorial, which is approximately a 10-minute drive away.

Rooms

The 76 rooms at this Sioux Falls hotel are equipped with comforts such as ironing equipment and air conditioning, as well as a flat-screen TV with satellite channels and a radio. A refrigerator, a stove top, and kitchenware are available upon request.

Eat & Drink

Situated just 1.2 km from Home2 Suites By Hilton Sioux Falls Sanford Medical Center hotel, the quick bites Giliberto's Mexican Taco Shop offers a Mexican menu.

Leisure & Business

The property has an indoor pool and a fitness suite. Also, at this hotel, guests can take advantage of a sports complex provided onsite. Finally, the Home2 Suites Sioux Falls houses a business centre featuring a xerox and a work desk.

“This all-suite hotel caters especially well to those visiting the Sanford Medical Center, with thoughtful touches extending to guest room design and even staff interactions. I appreciate the hotel's focus on extended stays, evidenced by in-room kitchens and the practical Spin2Cycle-a combined laundry and fitness area. Its free grocery delivery and late check-out flexibility, where available, enhance the experience.”
Hotel logo
James DavidEditor-in-Chief at Dogfriendly-hotels
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Select your room type

The hotel provides many room choices—family rooms, doubles, and pet-friendly suites—with breakfast, free cancellation, and special offers
King Studio Suite Non-Smoking
2 persons
40 m² 
1 King-size bed
Heating
Air conditioning
Queen Studio Two Queen Beds Non-Smoking
2 persons
40 m² 
2 King Size Beds
Heating
Air conditioning
King Studio Suite Hearing Access or Non-Smoking
2 persons
40 m² 
1 King-size bed
Heating
Air conditioning
Queen Studio Two Queen Beds Mobility Access or Non-Smoking
2 persons
40 m² 
2 King Size Beds
Heating
Air conditioning
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Rates & availability calendar

See current prices and availability for your chosen dates!

Facilities

Hotels feature amenities designed to keep both you and your pet comfortable

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • 24-hour reception
  • Express check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Luggage storage
  • Lift

Sports & Fitness

  • Fitness centre

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Laundry

Business

  • Business centre
  • Fax/Photocopying

Spa & Leisure

  • Indoor swimming pool
  • Jacuzzi

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Curtains
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Hotel location

1120 S Grange Avenue, Sioux Falls, South Dakota, United States, 57105
Map view
1120 S Grange Avenue, Sioux Falls, South Dakota, United States, 57105
Nearby
1305 W 18th St In the Sanford USD Medical Center
Sioux Empire Medical Museum
290 m
1001 SW Avenue
Sioux Falls Stadium
530 m
Restaurants
The Co-op of Sioux Falls
860 m
410 W 18th St
Azteca
1.1 km
811 S Minnesota Ave
Toppers Pizza
1.1 km
817 S Minnesota Ave
Taco John's
1.0 km
1100 S Minnesota Ave
Papa John's Pizza
1.1 km
711 S Minnesota Ave
Abelardo's Mexican Food
1.1 km
1200 S Minnesota Ave
Pho Quynh
960 m
1100 W 12th St
Explore Sioux Falls
Explore Sioux Falls
Top Attractions
Activities
Dining
Entertainment
Great Plains Zoo & Delbridge Museum
25 minutes walking
Home to over 1,000 animals, this zoo offers a unique museum featuring fossil exhibits. Family-friendly with seasonal events.
Michelangelo's David Replica
15 minutes walking
A stunning reproduction of Michelangelo's masterpiece located in a beautiful park. A perfect photo opportunity.
The Pettigrew Home and Museum
20 minutes walking
A historical house museum dedicated to the life of a local statesman. Features Victorian-era artifacts and guided tours.
Falls Park
30 minutes walking
A scenic park showcasing the stunning waterfalls of the Big Sioux River, with walking paths and picnic areas.
Sioux Falls Bike Trail
25 minutes walking
Scenic trails perfect for biking and walking, featuring views of nature and the city. Bike rentals available nearby.
Midco Aquatic Center
16 minutes walking
An indoor water park with slides and pools, great for families. Open year-round, check for specific attraction hours.
Azteca
13 minutes walking
A vibrant Mexican restaurant known for its flavorful enchiladas and margaritas. Vegetarian options available.
Toppers Pizza
13 minutes walking
Casual pizzeria offering a variety of unique pizzas and sides. Ideal for a quick meal, takeout available.
Lucky Lady Casino
15 minutes walking
A local casino offering a range of games and live entertainment. Great for an evening out with friends.
Downtown Sioux Falls
20 minutes walking
Vibrant area featuring shops, cafes, and live music venues. Perfect for a relaxed evening stroll.
Local transport and travel tips
City Centre
Sioux Falls10 min  ·  800 m
Airports
Sioux Falls Regional Airport (FSD)12 min  ·  7.9 km
Stronsay Airport (soy)130 min  ·  86.3 km
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Property information and rules
Check-in
from 15:00-23:59
Check-out
until 12 pm
Guest Parking
Public parking is possible on site for free.
Internet
is available in for free.
Breakfast
A buffet breakfast is served at affordable prices. 
Children & extra beds
There are no extra beds provided in a room.  There are no cots provided in a room. 
Pets
Pets are allowed on request.
Number of floors:
4
Number of rooms:
76
FAQs
About Home2 Suites By Hilton Sioux Falls Sanford Medical Center
What is the distance from Home2 Suites By Hilton Sioux Falls Sanford Medical Center to Sioux Falls Regional Airport?
The hotel is located 4 km from Sioux Falls Regional Airport.
What are the check-in and check-out times at Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
Check-in is at 15:00 and check-out is at 12:00.
Is parking available at Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
Public parking is available on-site for free without the need for a reservation.
What kind of room amenities can guests expect at Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
Each room includes a flat-screen TV, air conditioning, a kitchen with a refrigerator, microwave, and cookware, as well as complimentary Wi-Fi.
What dining options are available at Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
Buffet and American breakfast options are available for an additional charge.
What leisure facilities does Home2 Suites By Hilton Sioux Falls Sanford Medical Center feature?
The hotel features an indoor saline swimming pool, hot tub, and a 24-hour fitness center.
What are some nearby attractions to Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
Nearby attractions include Falls Park (6 minutes away), Denny Sanford Premier Center (6 minutes away), and the Sioux Empire Medical Museum (5 minutes' walk).
Does Home2 Suites By Hilton Sioux Falls Sanford Medical Center offer business services?
The hotel provides a business centre with meeting facilities and complimentary Wi-Fi.
What unique features does Home2 Suites By Hilton Sioux Falls Sanford Medical Center offer?
The hotel includes a Spin2Cycle facility, combining laundry and fitness options, alongside a complimentary grocery delivery service to guest suites.
Is there a smoking area at Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
The hotel is a non-smoking property.
What types of guests does Home2 Suites By Hilton Sioux Falls Sanford Medical Center cater to?
The hotel targets business and family travelers, especially those visiting the Sanford Medical Center.
Are there any restaurants within walking distance of Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
Restaurants within 1 km include Toppers Pizza, Taco John's, Abelardo's Mexican Food, Domino's Pizza, and Pho Quynh.

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